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Tetrapeptide-21 Soothing Peptide For Sensitive Skin Care
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Product Description
1. Mechanism of Action (MOA)
Tetrapeptide-21 is a innovative neurocosmetic peptide that specifically targets the underlying causes of skin sensitivity and irritation through a neuromodulatory pathway.
Inhibition of Neurogenic Inflammation:
The peptide acts as a specific antagonist of the Mas-related G-protein-coupled receptor X4 (MRGPRX4).
This receptor is primarily expressed on sensory neurons and is a key mediator of neurogenic inflammation and histamine-independent itching.
By blocking MRGPRX4 activation, Tetrapeptide-21 prevents the release of key neuropeptides, such as Substance P, which are responsible for causing vasodilation (redness), plasma extravasation (swelling), and irritation.
Calming Sensory Neurons:
It helps to reduce the hyper-reactivity of sensory neurons in the skin, thereby lowering the skin's overreaction to external aggressors (like pollutants, skincare ingredients, or physical stress).
Soothing & Anti-Irritant Effect:
Through this targeted mechanism, it provides a rapid and effective calming sensation, reducing visible redness and the feeling of discomfort associated with sensitive and reactive skin.
2. In Vitro Efficacy Data
Receptor Binding Assays: In vitro studies confirmed that Tetrapeptide-21 has a high binding affinity for the MRGPRX4 receptor, effectively acting as a competitive antagonist.
Inhibition of Neuropeptide Release: Cell-based models demonstrated that Tetrapeptide-21 significantly inhibits the release of Substance P from sensory neurons following stimulation.
Anti-Inflammatory Models: The peptide showed a strong ability to reduce the production of pro-inflammatory cytokines in skin cells co-cultured with stimulated neurons, validating its anti-inflammatory effect in the neuro-immune axis of the skin.
3. Clinical Results
Study Design: A 28-day clinical study was conducted on volunteers with self-assessed sensitive and reactive skin. A formulation containing 50 ppm of Tetrapeptide-21 was applied twice daily.
Key Findings:
Reduction in Stinging & Itching: Subjects reported a significant decrease in the sensation of stinging, itching, and burning after just a few applications.
Decreased Visible Redness: Clinical grading and colorimetric analysis measured a statistically significant reduction in facial redness and skin reactivity.
Improved Skin Tolerance: Participants reported that their skin was better able to tolerate other potentially irritating products (e.g., retinoids, acids) when used in conjunction with the Tetrapeptide-21 formulation.
Enhanced Skin Comfort: Over 85% of subjects agreed that their skin felt more comfortable, soothed, and less reactive.
Safety Profile
Excellent topical safety. Non-irritating, non-sensitizing, and non-cytotoxic at recommended use levels. Specifically designed for sensitive skin.
Biocompatibility
As a biomimetic peptide, it is well-tolerated.
Formulation Compatibility
*Highly soluble and stable in aqueous phases. *Compatible with a wide range of cosmetic ingredients, including other soothing agents, barrier lipids, and standard emulsion systems.
*Ideal for incorporation into sensitive skin creams, soothing serums, after-sun products, post-procedure formulations, and products designed to reduce retinoid irritation.
*Ideal for incorporation into sensitive skin creams, soothing serums, after-sun products, post-procedure formulations, and products designed to reduce retinoid irritation.
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Recommended Usage & Dosage
Recommended Concentration: 20 to 100 ppm (0.002% - 0.01%).
Typical Use Level: 50 ppm (0.005%) is clinically proven to be effective for significant soothing and anti-redness effects.
Suggested Applications:
Primary: Products for sensitive, reactive, and intolerant skin; calming serums; anti-redness creams.
Secondary: Pre/post-procedure care, after-shave, formulations to boost tolerance to active ingredients (e.g., alongside retinoids or vitamin C).
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Targeted Neurocosmetic Action
Uniquely targets the MRGPRX4 receptor to directly inhibit the cause of neurogenic inflammation.
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Rapid Soothing & Calming
Provides quick relief from sensations of stinging, itching, and burning, addressing both the signs and symptoms of sensitivity.
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Reduces Visible Redness
Clinically proven to decrease redness associated with skin reactivity.
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Boosts Skin Tolerance
Helps strengthen the skin's resilience, allowing it to better tolerate environmental stressors and active skincare.
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Ideal for Sensitive Skin
Its specific mechanism and excellent safety profile make it a cornerstone ingredient for any sensitive skin formulation.
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Science-Backed Innovation
The MRGPRX4 target is a cutting-edge pathway in dermatology, providing a strong and credible scientific story.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available